Preimplantation genetic diagnosis (PGD)

Preimplantation Genetic Diagnosis (PGD) stands as a cutting-edge procedure in assisted reproductive technology, offering a sophisticated approach to identify chromosomal and genetic abnormalities within embryos derived from an in vitro fertilization (IVF) cycle. This technique plays a crucial role in detecting genetic issues before the embryos are transferred into the womb and implanted, ensuring a more informed and tailored reproductive journey.

At Parens International, we proudly provide PGD services utilizing the advanced Next Generation Sequencing (NGS) method. This approach significantly elevates accuracy and precision, enabling the detection of chromosomal abnormalities and other genetic complications with unparalleled efficacy.

Our comprehensive screening encompasses 24 chromosomes, boasting an exceptional precision rate of 99.9%. This thorough examination serves to exclude a spectrum of conditions, including but not limited to Down’s syndrome, Patau syndrome, Huntington’s disease, Cystic Fibrosis, Edwards syndrome, BRCA, Myotonic dystrophy, and Fragile X syndrome.

Preimplantation Genetic Diagnosis (PGD) serves as a proactive measure in ensuring a healthier start to life. It is a vital tool for detecting abnormalities inherited from one or both parents in embryos conceived through in vitro fertilization (IVF). By conducting these tests before embryo implantation, PGD significantly reduces the risk of giving birth to a child with known genetic conditions.

Through PGD, parents can make informed decisions and enhance the success and well-being of their reproductive journey.

PGD is particularly beneficial for individuals who may carry or transfer chromosomal abnormalities. This procedure provides couples with the opportunity to increase the likelihood of having a healthy child while avoiding the emotional challenges associated with pregnancy termination. To determine whether PGD is necessary, screening is recommended for couples falling into the following categories:

• Individuals who either have a chromosomal disorder or a genetically caused disease
• Couples with a history of having a child with a genetic abnormality
• Those who have undergone pregnancy termination following a diagnosis of chromosomal or genetic abnormalities in fetus

Our focus at Parens International extends to delivering specialized PGD services, combining advanced technology with comprehensive support. Our expert team can provide guidance on whether PGD is necessary for your specific circumstances, ensuring personalized care on your path to a healthy pregnancy.

The PGD procedure at Parens International involves a multi-step approach:

1. We start with the acquisition of fresh embryos through IVF.
2. To maximize the egg yield, ovarian stimulation is employed, ensuring the availability of optimal candidates for fertilization using ICSI (intra-cytoplasmic sperm injection).
3. The resulting embryos are then cultured in a specialized environment for 5 or 6 days, reaching the crucial blastocyst stage.
4. At this point, a trophectoderm biopsy is performed to collect cells for analysis.
5. The samples are analyzed, allowing the identification of the healthiest embryo for implantation.

What sets PGD apart is its consideration of both morphological and genetic aspects during embryo selection. In contrast to a regular IVF cycle, where morphology alone guides the selection, PGD brings an additional layer of scrutiny.

Any surplus embryos are frozen and stored for future use, providing a strategic reserve in case the initial procedure doesn’t result in a viable pregnancy. Moreover, the PGD test offers the unique capability to choose the baby’s sex, adding a personalized dimension to the family-building journey.

While the PGD process entails meticulous steps and may take up to 21 working days to obtain results, the investment is invaluable when considering the assurance of a healthy child.

Parens International, with a decade of experience, has been a reliable partner for couples across Europe facing infertility challenges. Our comprehensive range of services spans from IUI to fully-supported surrogacy programs, addressing diverse needs.

For those contemplating PGD or seeking fertility advice, a consultation with our experts can illuminate the possibilities and guide you toward securing your future path to parenthood.